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Carbamazepine: Concomitant administration of Diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases.

Current medical therapy for chronic anal fissure focuses on alleviating the two main pathologies by using anal sphincter relaxing topical ointments and laxative to treat associated constipation.

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Results of lateral internal sphincterotomy for chronic anal fissure with particular reference to quality of life.

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It is now almost 30 years since the first incident.

The modern practice is to insert the ointment over an anal dilator, which in addition helps relieve sphincter spasm.

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When used as monotherapy, usual starting doses are 120 to 240 mg once daily.

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OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your professional.

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Within a couple of days of use the pain had decreased significantly.

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Concomitant administration of oral diltiazem with carbamazepine has been reported to result in elevated plasma levels of carbamazepine (by 40 to 72%), resulting in toxicity in some cases.

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When Diltiazem was coadministered with a high fat content breakfast, the extent of Diltiazem absorption was not affected; T max, however, occurred slightly earlier.

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As no commercially manufactured formulation of topical 2% diltiazem has been approved yet by the Food and Drug Administration for the treatment of anal fissure, prescriptions for the medication need to be extemporaneously compounded by retail pharmacies.

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Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure.

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METHODS Three studies were conducted, each involving 10 healthy volunteers.

Prevalence represents new and pre-existing cases alive on a certain date, in contrast to incidence which reflects new cases of a condition diagnosed during a given period of time.

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