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This initial decrease in MAP did not appear to have affected the overall action of ranolazine on muscle microvasculature.

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Because many drugs are excreted in human milk and because of the potential for serious adverse reactions from ranolazine in nursing infants, a decision should be made whether to discontinue nursing or to discontinue Ranexa, taking into account the importance of the drug to the mother.

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Quality of life assessments: There were significant improvements in the frequency of angina following PCI in both arms, with no differences between ranolazine vs.

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They acknowledged that the study was limited by the use of prespecified efficacy analyses, which precluded additional analyses that might have seen a greater difference in clinical endpoints.

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