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With the small number of RCTs which conclusions eventually are based on, we see no good reasons for not performing a full systematic review with meta-analyses of randomized placebo-controlled trials when guidelines are being made.

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The findings of this network meta-analysis are extremely important to clinic practice.

To evaluate consistency, we classified conclusions of trials and systematic reviews as positive (the medication is beneficial), negative (the medication is harmful or not beneficial), or uncertain (the estimates are imprecise, the evidence unclear, or the results inconsistent) ().

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Amy Williams calls for systematic and institutional changes to address this modern plague of mental and physical exhaustion.

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