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The signs and symptoms of acute bronchitis regressed readily in all treatment groups, but regression was slower and less complete in the patients treated with placebo.

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The risk of adverse effects should be weighed against the severity of disease and patient comorbidities prior to initiating antibiotic treatment.

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Prophylaxis is indicated in high risk conditions for development of renal scarring or urosepsis (dilated VUR, severe obstruction, recurrent symptomatic UTI, especially with bladder instability or voiding dysfunction and girls with frequent UTIs for symptomatic relief, infective stones, up to reconstruction of renal abnormality predisposed to UTI, symptomatic VUR, at risk patients for recurrent pyelonephritis (more than one episode of pyelonephritis), symptomatic reflux, high risk of recurrent UTI and renal scarring, children less than 8 years with VUR and recurrent symptomatic UTIs, VUR in neurogenic bladder, children less than 18 months with nonreflux acute pyelonephritis, up to completion of imaging procedures and institution of treatment strategy, susceptible patients to recurrent UTI without any documented source, immune deficiency, and up to resolution of obstruction.

International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.

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Treating bacterial infections or preventing bacterial infections before, during, or after certain surgeries.

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Topical antibiotics such as mupirocin (Bactroban) and fusidic acid (not available in the United States) are the preferred first-line therapy for impetigo involving limited body surface area.

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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient.

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