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The beneficial effect of low dose naltrexone, LDN, was discovered by Bernard Bihari, MD ()(), a physician in New York City who found that a small dose (3 mg) of naltrexone taken as a capsule at bedtime blocks the opiate receptors in the brain for a few hours during sleep, which then stimulates the brain to increase production of endorphins over the next 24 hours.

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Australia, who is convinced of the benefits of using LDN for his own primary lateral sclerosis, has recently updated his prior message of November 2004, in which he reported on the effects of LDN in several people with motor neuron diseases.

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On April 7, 2006, at the Lister Hill Auditorium of the National Library of Medicine in Bethesda, MD, doctors, researchers, and LDN advocates gathered for a day-long series of groundbreaking presentations.

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